Demethylation and auto-oxidation of different cobalt-=bleomycin complexes.
نویسندگان
چکیده
Demethylation of Co-bleomycin A2 by heating yields three different complexes: form I and form II and "orange" Co-bleomycin-demethyl A2. These complexes can be separated by HPLC and show different 1H NMR spectra. Preparation of Co-bleomycin-demethyl A2 by chelation of bleomycin-demethyl A2 with cobalt yields a Co-bleomycin-demethyl A2, which is auto-oxidized into Co-bleomycin A1.
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 35 7 شماره
صفحات -
تاریخ انتشار 1982